Other fibro medicines


Duloxetine, sold under the brand name Cymbalta, has been available for sufferers since 2004. It is typically used as an antidepressant, though in women with fibromyalgia, it has been shown to be an effective pain relief medication.

Duloxetine works by affecting levels of serotonin and norepinephrine in the brain. These are neurotransmitters which affect mood and pain sensations. In a recent study involving fibromyalgia sufferers, women using duloxetine reported significant improvement in their muscle pain and stiffness.

Thirty percent of duloxetine users report a 50% reduction in their fibromyalgia pain. Duloxetine has also been shown to improve daily functioning.

Duloxetine is available by prescription for women suffering from fibromyalgia. Common side effects include nausea and dry mouth. Unfortunately, duloxetine does not appear to be effective in men with fibromyalgia.


Pregabalin is sold under the brand name Lyrica. It is now available in the European Union and for certain conditions in the United States and Canada. Lyrica is a nerve pain medication commonly used in diabetics. It has recently shown to be useful in reducing pain caused by fibromyalgia.

Pregabalin works by calming over-excited nerve cells. Nerve cells are responsible for receiving pain messages from the outside world. People suffering from fibromyalgia often have overactive nerve cells.

In a recent study involving fibromyalgia patients, pregabalin was shown to vastly reduce symptoms of fibromyalgia pain. It also worked to improve sleep and reduce fatigue symptoms. In fact, almost 50% of users claim a 30% reduction in overall symptoms. Side effects include dizziness and sleepiness.


Pramipexole has recently been shown to reduce pain considerably in fibromyalgia patients. Sold under the brand name Mirapex, pramipexole is usually used to treat Parkinson’s patients. It is now available for use by a minority of fibromyalgia patients.

Pramipexole is a dopamine receptor agonist. This means that the drug works to stimulate the production of dopamine, a chemical transmitter in your brain. Dopamine works to reduce your body’s response to pain.

In recent studies, 8 out 10 fibromyalgia patients reported a 30% improvement in pain. 4 in 10 fibromyalgia sufferers reported a 50% reduction in pain. Nausea and constipation are the most common side effects of pramipexole.

Cox-II Inhibitors

Cox-II inhibitors are a type of anti-inflammatory, used to minimize swelling, joint and muscle pain. Celebrex and Vioxx are types of Cox-II inhibitors (though Vioxx is no longer available on the market). Cox-II inhibitors can help to reduce the muscle pain associated with fibromyalgia.

Cox-II inhibitors work by blocking Cox-II enzymes. These enzymes control the production of prostaglandins, which cause pain and inflammation. Unlike other anti-inflammatories, like NSAIDs, Cox-II inhibitors do not affect Cox-I enzymes, which are necessary to maintain the lining of your stomach and kidneys.

Cox-II inhibitors therefore decrease pain without causing gastrointestinal bleeding. Side effects include swelling and increased blood pressure.

Table of Contents
1. New Medicines for FMS
2. Drugs that reduce pain
3. Decreasing pain signals
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